That's unusual to have major discomfort at the site of a biopsy. Is it inflamed? If so I'd contact the Doctor pronto, could be an infection, otherwise I'd still contact him/her first thing Monday. I've had lots of skin cancers and chunks taken for testing and don't remember major discomfort. Sounds like you need to keep a close eye on it until the Doc takes a look.
Well if you grit your teeth and bare it; it could wear on your teeth. In the old day's they'd bite on a bullet; not knowing about the evils of lead poisoning.If you can't at least cover it with a bandage, I suggest medicinal amounts of a good strong alcohol taken orally, until it heals up a bit or the pain goes away. I know this is old school thinking, but it still works .